Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein -subunit
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چکیده
منابع مشابه
Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein -subunit
Heterotrimeric G protein (G ) subunits possess intrinsic GTPase activity that leads to functional deactivation with a rate constant of 2 min 1 at 30°C. GTP hydrolysis causes conformational changes in three regions of G , including Switch I and Switch II. Mutation of G2023A in Switch II of G i1 accelerates the rates of both GTP hydrolysis and conformational change, which is measured by the loss ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0304091101